Drug interactions
Avanafil + Dasatinib
Severity: Moderate
Avanafil and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib weakly inhibits CYP3A4 and may modestly increase avanafil exposure. This could increase PDE5-related adverse effects such as hypotension and headache.
What this interaction means in plain words
Avanafil and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Dasatinib belongs to Oncology.
Why it happens
Dasatinib inhibits CYP3A4, reducing avanafil clearance.
What to do
Limit avanafil to 50 mg no more than once every 24 hours. Monitor for hypotension and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Avanafil with Dasatinib?
MediHelp rates the interaction as moderate. Avanafil and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib weakly inhibits CYP3A4 and may modestly increase avanafil exposure. This could increase PDE5-related adverse effects such as hypotension and headache.
How serious is the interaction between Avanafil and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg no more than once every 24 hours. Monitor for hypotension and other adverse effects.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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