Drug interactions
Avanafil + Eplerenone
Severity: Moderate
Avanafil and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may add modestly to the blood pressure lowering of eplerenone. Dizziness or symptomatic hypotension is possible, particularly in volume-depleted patients.
What this interaction means in plain words
Avanafil and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Eplerenone belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from PDE5-mediated vasodilation and aldosterone antagonism with diuresis.
What to do
Start avanafil at a low dose in patients with stable blood pressure on eplerenone. Monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Avanafil with Eplerenone?
MediHelp rates the interaction as moderate. Avanafil and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may add modestly to the blood pressure lowering of eplerenone. Dizziness or symptomatic hypotension is possible, particularly in volume-depleted patients.
How serious is the interaction between Avanafil and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at a low dose in patients with stable blood pressure on eplerenone. Monitor blood pressure and orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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