Drug interactions
Avanafil + Esmolol
Severity: Moderate
Avanafil and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a vasodilator through PDE5 inhibition and can add to the blood pressure lowering of esmolol. Symptomatic hypotension, dizziness or syncope may occur, particularly at treatment start.
What this interaction means in plain words
Avanafil and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Esmolol belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Confirm the patient is hemodynamically stable before starting avanafil and monitor blood pressure and symptoms of orthostasis. Counsel the patient to rise slowly and to report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Avanafil with Esmolol?
MediHelp rates the interaction as moderate. Avanafil and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a vasodilator through PDE5 inhibition and can add to the blood pressure lowering of esmolol. Symptomatic hypotension, dizziness or syncope may occur, particularly at treatment start.
How serious is the interaction between Avanafil and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm the patient is hemodynamically stable before starting avanafil and monitor blood pressure and symptoms of orthostasis. Counsel the patient to rise slowly and to report dizziness or fainting.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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