Drug interactions
Avanafil + Fluvoxamine
Severity: Moderate
Avanafil and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine weakly to moderately inhibits CYP3A4 and may increase avanafil exposure. This can intensify vasodilatory adverse effects of avanafil.
What this interaction means in plain words
Avanafil and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of avanafil by fluvoxamine reduces its clearance.
What to do
Keep avanafil at 50 mg or less, no more than once every 24 hours, and monitor for hypotension, headache and prolonged erection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Avanafil with Fluvoxamine?
MediHelp rates the interaction as moderate. Avanafil and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine weakly to moderately inhibits CYP3A4 and may increase avanafil exposure. This can intensify vasodilatory adverse effects of avanafil.
How serious is the interaction between Avanafil and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep avanafil at 50 mg or less, no more than once every 24 hours, and monitor for hypotension, headache and prolonged erection.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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