Drug interactions
Avanafil + Furosemide
Severity: Moderate
Avanafil and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil lowers blood pressure through vasodilation, and furosemide can cause volume depletion. Together they may cause symptomatic hypotension, especially in volume-depleted patients.
What this interaction means in plain words
Avanafil and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Furosemide belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from vasodilation and diuretic-induced volume reduction.
What to do
Assess volume status and blood pressure before starting avanafil. Monitor for orthostatic symptoms and start at a low dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Avanafil with Furosemide?
MediHelp rates the interaction as moderate. Avanafil and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil lowers blood pressure through vasodilation, and furosemide can cause volume depletion. Together they may cause symptomatic hypotension, especially in volume-depleted patients.
How serious is the interaction between Avanafil and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure before starting avanafil. Monitor for orthostatic symptoms and start at a low dose.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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