Drug interactions
Avanafil + Labetalol
Severity: Moderate
Avanafil and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks alpha-1 and beta receptors and lowers blood pressure, and avanafil adds vasodilation. The alpha-blocking component makes symptomatic hypotension more likely.
What this interaction means in plain words
Avanafil and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Labetalol belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects, with alpha-1 blockade reinforcing PDE5 inhibitor vasodilation.
What to do
Make sure the patient is stable on labetalol before starting avanafil, begin with the lowest dose, and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Avanafil with Labetalol?
MediHelp rates the interaction as moderate. Avanafil and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks alpha-1 and beta receptors and lowers blood pressure, and avanafil adds vasodilation. The alpha-blocking component makes symptomatic hypotension more likely.
How serious is the interaction between Avanafil and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Make sure the patient is stable on labetalol before starting avanafil, begin with the lowest dose, and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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