Drug interactions
Avanafil + Losartan
Severity: Moderate
Avanafil and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil can potentiate the blood pressure reduction of losartan. Symptomatic hypotension or dizziness may occur.
What this interaction means in plain words
Avanafil and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Losartan belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Ensure blood pressure is controlled before starting avanafil and monitor after initiation. Advise slow postural changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Avanafil with Losartan?
MediHelp rates the interaction as moderate. Avanafil and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil can potentiate the blood pressure reduction of losartan. Symptomatic hypotension or dizziness may occur.
How serious is the interaction between Avanafil and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is controlled before starting avanafil and monitor after initiation. Advise slow postural changes.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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