Drug interactions
Avapritinib + Posaconazole
Severity: Major
Avapritinib and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and posaconazole markedly raises its exposure. This increases the risk of intracranial hemorrhage, cognitive effects, and other toxicities.
What this interaction means in plain words
Avapritinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of avapritinib.
What to do
Avoid the combination and use a non-CYP3A4-inhibiting antifungal. If unavoidable, reduce the avapritinib dose per labeling and monitor for cognitive and bleeding events.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Posaconazole?
MediHelp rates the interaction as major. Avapritinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate, and posaconazole markedly raises its exposure. This increases the risk of intracranial hemorrhage, cognitive effects, and other toxicities.
How serious is the interaction between Avapritinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antifungal. If unavoidable, reduce the avapritinib dose per labeling and monitor for cognitive and bleeding events.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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