Drug interactions
Avapritinib + Propofol
Severity: Moderate
Avapritinib and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause sedation and cognitive effects, which may add to the depressant effect of propofol. Propofol's weak CYP3A4 inhibition might also modestly increase avapritinib exposure, though this is not well documented.
What this interaction means in plain words
Avapritinib and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible weak CYP3A4 inhibition by propofol.
What to do
Titrate propofol to effect with careful sedation monitoring. Watch for increased avapritinib adverse effects such as cognitive changes if propofol is given over a prolonged period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Propofol?
MediHelp rates the interaction as moderate. Avapritinib and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause sedation and cognitive effects, which may add to the depressant effect of propofol. Propofol's weak CYP3A4 inhibition might also modestly increase avapritinib exposure, though this is not well documented.
How serious is the interaction between Avapritinib and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with careful sedation monitoring. Watch for increased avapritinib adverse effects such as cognitive changes if propofol is given over a prolonged period.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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