Drug interactions
Avatrombopag + Ribociclib
Severity: Minor
Avatrombopag and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avatrombopag is metabolized by CYP2C9 and CYP3A4. Moderate CYP3A4 inhibition by ribociclib may modestly raise avatrombopag exposure, with little expected effect given the dual pathways.
What this interaction means in plain words
Avatrombopag and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avatrombopag belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, a partial clearance pathway for avatrombopag.
What to do
No dose adjustment is needed. Monitor platelet counts as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Ribociclib?
MediHelp rates the interaction as minor. Avatrombopag and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avatrombopag is metabolized by CYP2C9 and CYP3A4. Moderate CYP3A4 inhibition by ribociclib may modestly raise avatrombopag exposure, with little expected effect given the dual pathways.
How serious is the interaction between Avatrombopag and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor platelet counts as usual.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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