Drug interactions
Avatrombopag + Voriconazole
Severity: Moderate
Avatrombopag and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises avatrombopag exposure, which can increase platelet counts and thromboembolic risk.
What this interaction means in plain words
Avatrombopag and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and CYP2C9 by voriconazole decreases avatrombopag clearance.
What to do
Use the reduced avatrombopag starting dose recommended in labeling for ITP. Monitor platelet counts and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avatrombopag and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Voriconazole?
MediHelp rates the interaction as moderate. Avatrombopag and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises avatrombopag exposure, which can increase platelet counts and thromboembolic risk.
How serious is the interaction between Avatrombopag and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced avatrombopag starting dose recommended in labeling for ITP. Monitor platelet counts and adjust the dose accordingly.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
