Drug interactions
Aztreonam + Cefpirome
Severity: Minor
Aztreonam and Cefpirome: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam and cefpirome are both beta-lactam antibiotics with activity against gram-negative bacteria, and the combination can show additive or synergistic killing of some Enterobacteriaceae in vitro. This is generally a therapeutic benefit rather than a harmful interaction, though both drugs can cause hypersensitivity reactions and cross-reactivity is possible with cephalosporins with similar side chains.
What this interaction means in plain words
Aztreonam and Cefpirome have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Cefpirome belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic effect through binding of different penicillin-binding proteins in gram-negative bacteria.
What to do
No routine adjustment is needed; use only when the combined spectrum is clinically intended and guided by culture results. Monitor for hypersensitivity reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Aztreonam with Cefpirome?
MediHelp rates the interaction as minor. Aztreonam and Cefpirome have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam and cefpirome are both beta-lactam antibiotics with activity against gram-negative bacteria, and the combination can show additive or synergistic killing of some Enterobacteriaceae in vitro. This is generally a therapeutic benefit rather than a harmful interaction, though both drugs can cause hypersensitivity reactions and cross-reactivity is possible with cephalosporins with similar side chains.
How serious is the interaction between Aztreonam and Cefpirome?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; use only when the combined spectrum is clinically intended and guided by culture results. Monitor for hypersensitivity reactions.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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