Drug interactions
Benazepril + Silodosin
Severity: Minor
Benazepril and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors and alpha-blockers both lower blood pressure, so combining them may cause additive hypotension, particularly at initiation. Silodosin trials showed no major problems with common antihypertensives, but symptomatic orthostasis can occur.
What this interaction means in plain words
Benazepril and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade and inhibition of angiotensin-II formation.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or the dose changed. Advise slow position changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Silodosin?
MediHelp rates the interaction as minor. Benazepril and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors and alpha-blockers both lower blood pressure, so combining them may cause additive hypotension, particularly at initiation. Silodosin trials showed no major problems with common antihypertensives, but symptomatic orthostasis can occur.
How serious is the interaction between Benazepril and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or the dose changed. Advise slow position changes.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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