Drug interactions
Bortezomib + Enzalutamide
Severity: Moderate
Bortezomib and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower bortezomib exposure, since bortezomib is partly cleared by CYP3A4. Reduced exposure could compromise antineoplastic efficacy.
What this interaction means in plain words
Bortezomib and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and increases the hepatic metabolism of bortezomib.
What to do
Monitor disease response closely and consider an alternative to enzalutamide if loss of bortezomib effect is suspected. Avoid starting or stopping strong inducers mid-cycle without review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Enzalutamide?
MediHelp rates the interaction as moderate. Bortezomib and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may lower bortezomib exposure, since bortezomib is partly cleared by CYP3A4. Reduced exposure could compromise antineoplastic efficacy.
How serious is the interaction between Bortezomib and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response closely and consider an alternative to enzalutamide if loss of bortezomib effect is suspected. Avoid starting or stopping strong inducers mid-cycle without review.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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