Drug interactions
Bortezomib + Tucatinib
Severity: Moderate
Bortezomib and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may increase bortezomib exposure. This could worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing bortezomib metabolism.
What to do
Monitor for neuropathy and cytopenias and consider reducing the bortezomib dose. Use alternatives if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Bortezomib with Tucatinib?
MediHelp rates the interaction as moderate. Bortezomib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and may increase bortezomib exposure. This could worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and cytopenias and consider reducing the bortezomib dose. Use alternatives if possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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