Drug interactions
Bosutinib + Mitomycin
Severity: Moderate
Bosutinib and Mitomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib can inhibit P-glycoprotein, which may increase exposure to P-gp substrates. Bosutinib also causes myelosuppression, so overlapping marrow toxicity with mitomycin is a more relevant concern than the transporter effect.
What this interaction means in plain words
Bosutinib and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Mitomycin belongs to Oncology.
Why it happens
Additive myelosuppression, plus possible P-gp inhibition by bosutinib raising mitomycin exposure.
What to do
Monitor complete blood counts closely and adjust or hold either drug if significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Mitomycin?
MediHelp rates the interaction as moderate. Bosutinib and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib can inhibit P-glycoprotein, which may increase exposure to P-gp substrates. Bosutinib also causes myelosuppression, so overlapping marrow toxicity with mitomycin is a more relevant concern than the transporter effect.
How serious is the interaction between Bosutinib and Mitomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and adjust or hold either drug if significant cytopenias occur.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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