Drug interactions
Brexpiprazole + Posaconazole
Severity: Moderate
Brexpiprazole and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases brexpiprazole exposure, raising the risk of sedation, akathisia, orthostatic hypotension and other dose-related adverse effects. Labeling recommends a dose reduction with strong CYP3A4 inhibitors.
What this interaction means in plain words
Brexpiprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, a main metabolic pathway of brexpiprazole.
What to do
Give half of the usual brexpiprazole dose during posaconazole therapy, and a quarter if a strong or moderate CYP2D6 inhibitor is also used. Return to the usual dose after posaconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Posaconazole?
MediHelp rates the interaction as moderate. Brexpiprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases brexpiprazole exposure, raising the risk of sedation, akathisia, orthostatic hypotension and other dose-related adverse effects. Labeling recommends a dose reduction with strong CYP3A4 inhibitors.
How serious is the interaction between Brexpiprazole and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give half of the usual brexpiprazole dose during posaconazole therapy, and a quarter if a strong or moderate CYP2D6 inhibitor is also used. Return to the usual dose after posaconazole is stopped.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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