Drug interactions
Brexpiprazole + Propofol
Severity: Moderate
Brexpiprazole and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole may add to the sedative and hypotensive effects of propofol during anaesthesia or procedural sedation. Propofol requirements may be lower and recovery may be slower.
What this interaction means in plain words
Brexpiprazole and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilatory or alpha-adrenergic hypotensive effects.
What to do
Titrate propofol to effect and monitor blood pressure, airway and sedation depth. Inform the anaesthesia team about antipsychotic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Propofol
Frequently asked questions
Can I take Brexpiprazole with Propofol?
MediHelp rates the interaction as moderate. Brexpiprazole and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole may add to the sedative and hypotensive effects of propofol during anaesthesia or procedural sedation. Propofol requirements may be lower and recovery may be slower.
How serious is the interaction between Brexpiprazole and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor blood pressure, airway and sedation depth. Inform the anaesthesia team about antipsychotic use.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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