Drug interactions
Brexpiprazole + Tasimelteon
Severity: Minor
Brexpiprazole and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is a melatonin receptor agonist that can cause somnolence, so it may add to brexpiprazole's sedative effects. The clinical effect is usually modest.
What this interaction means in plain words
Brexpiprazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Additive sedative effects; no significant pharmacokinetic interaction is expected.
What to do
Monitor for daytime drowsiness and advise caution with driving. Take tasimelteon at a consistent time before bedtime.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Tasimelteon
Frequently asked questions
Can I take Brexpiprazole with Tasimelteon?
MediHelp rates the interaction as minor. Brexpiprazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is a melatonin receptor agonist that can cause somnolence, so it may add to brexpiprazole's sedative effects. The clinical effect is usually modest.
How serious is the interaction between Brexpiprazole and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime drowsiness and advise caution with driving. Take tasimelteon at a consistent time before bedtime.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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