Drug interactions
Brexpiprazole + Ticlopidine
Severity: Moderate
Brexpiprazole and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2D6 and may raise brexpiprazole exposure, increasing the risk of sedation, akathisia and other adverse effects. The effect is larger if a CYP3A4 inhibitor is also given.
What this interaction means in plain words
Brexpiprazole and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated brexpiprazole metabolism by ticlopidine.
What to do
Reduce brexpiprazole to about half the usual dose with a CYP2D6 inhibitor, and to a quarter if combined with a strong or moderate CYP3A4 inhibitor. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Ticlopidine?
MediHelp rates the interaction as moderate. Brexpiprazole and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2D6 and may raise brexpiprazole exposure, increasing the risk of sedation, akathisia and other adverse effects. The effect is larger if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce brexpiprazole to about half the usual dose with a CYP2D6 inhibitor, and to a quarter if combined with a strong or moderate CYP3A4 inhibitor. Monitor for adverse effects.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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