Drug interactions
Brexpiprazole + Tucatinib
Severity: Moderate
Brexpiprazole and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase brexpiprazole concentrations, raising the risk of dose-related adverse effects such as sedation, akathisia and orthostasis.
What this interaction means in plain words
Brexpiprazole and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of brexpiprazole by tucatinib.
What to do
Monitor for brexpiprazole adverse effects and consider reducing its dose, as labeling advises for strong CYP3A4 inhibitors, while tucatinib is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Brexpiprazole with Tucatinib?
MediHelp rates the interaction as moderate. Brexpiprazole and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase brexpiprazole concentrations, raising the risk of dose-related adverse effects such as sedation, akathisia and orthostasis.
How serious is the interaction between Brexpiprazole and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and consider reducing its dose, as labeling advises for strong CYP3A4 inhibitors, while tucatinib is given.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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