Drug interactions
Bromocriptine + Chlorpromazine
Severity: Moderate
Bromocriptine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks dopamine receptors and opposes the effect of bromocriptine, a dopamine agonist. This can reduce bromocriptine's efficacy in Parkinson's disease or hyperprolactinemia and may worsen psychosis.
What this interaction means in plain words
Bromocriptine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination in Parkinson's disease and consider an antipsychotic with less D2 blockade such as quetiapine. Monitor symptom control and prolactin levels if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Chlorpromazine?
MediHelp rates the interaction as moderate. Bromocriptine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks dopamine receptors and opposes the effect of bromocriptine, a dopamine agonist. This can reduce bromocriptine's efficacy in Parkinson's disease or hyperprolactinemia and may worsen psychosis.
How serious is the interaction between Bromocriptine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in Parkinson's disease and consider an antipsychotic with less D2 blockade such as quetiapine. Monitor symptom control and prolactin levels if used.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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