Drug interactions
Bromocriptine + Enzalutamide
Severity: Moderate
Bromocriptine and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower bromocriptine concentrations. Therapeutic effect may be lost.
What this interaction means in plain words
Bromocriptine and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing bromocriptine metabolism.
What to do
Monitor prolactin or symptom control and increase the bromocriptine dose if needed. Consider an alternative dopamine agonist if the response remains inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Bromocriptine with Enzalutamide?
MediHelp rates the interaction as moderate. Bromocriptine and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower bromocriptine concentrations. Therapeutic effect may be lost.
How serious is the interaction between Bromocriptine and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin or symptom control and increase the bromocriptine dose if needed. Consider an alternative dopamine agonist if the response remains inadequate.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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