Drug interactions
Bromocriptine + Tucatinib
Severity: Moderate
Bromocriptine and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may increase bromocriptine exposure, increasing risk of hypotension, nausea and CNS effects.
What this interaction means in plain words
Bromocriptine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism.
What to do
Monitor blood pressure and dopaminergic adverse effects and reduce the bromocriptine dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Bromocriptine with Tucatinib?
MediHelp rates the interaction as moderate. Bromocriptine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and may increase bromocriptine exposure, increasing risk of hypotension, nausea and CNS effects.
How serious is the interaction between Bromocriptine and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and dopaminergic adverse effects and reduce the bromocriptine dose if they appear.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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