Drug interactions
Budesonide-formoterol + Dofetilide
Severity: Major
Budesonide-formoterol and Dofetilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a high risk of torsades de pointes and formoterol may add to QT prolongation and lower potassium. Arrhythmia risk is substantial.
What this interaction means in plain words
Budesonide-formoterol and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Dofetilide belongs to Cardiovascular.
Why it happens
Additive QT prolongation with beta-2 agonist-related hypokalemia.
What to do
Avoid unless essential; monitor continuous ECG during dofetilide initiation and keep potassium and magnesium normal. Consider an alternative bronchodilator.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Dofetilide?
MediHelp rates the interaction as major. Budesonide-formoterol and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide has a high risk of torsades de pointes and formoterol may add to QT prolongation and lower potassium. Arrhythmia risk is substantial.
How serious is the interaction between Budesonide-formoterol and Dofetilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless essential; monitor continuous ECG during dofetilide initiation and keep potassium and magnesium normal. Consider an alternative bronchodilator.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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