Drug interactions
Bumetanide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Bumetanide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide with hydrochlorothiazide produces powerful additive diuresis. This can cause volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment, with irbesartan adding to the renal hemodynamic effect.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Sequential nephron blockade by loop and thiazide diuretics gives additive natriuresis and potassium loss.
What to do
Monitor electrolytes, creatinine, weight and blood pressure after starting or adjusting doses. Reduce diuretic doses if volume depletion or electrolyte disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide with hydrochlorothiazide produces powerful additive diuresis. This can cause volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment, with irbesartan adding to the renal hemodynamic effect.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure after starting or adjusting doses. Reduce diuretic doses if volume depletion or electrolyte disturbance occurs.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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