Drug interactions
Bumetanide + Hydrochlorothiazide
Severity: Moderate
Bumetanide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop and a thiazide diuretic produces sequential nephron blockade, causing marked diuresis. This can lead to severe hypokalaemia, hyponatraemia, hypomagnesaemia, dehydration and hypotension.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte-wasting effects at different nephron sites.
What to do
Monitor electrolytes, renal function, weight and blood pressure closely, especially in the first days of therapy. Replace potassium and magnesium as needed and adjust diuretic doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop and a thiazide diuretic produces sequential nephron blockade, causing marked diuresis. This can lead to severe hypokalaemia, hyponatraemia, hypomagnesaemia, dehydration and hypotension.
How serious is the interaction between Bumetanide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, especially in the first days of therapy. Replace potassium and magnesium as needed and adjust diuretic doses.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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