Drug interactions
Bumetanide + Trazodone
Severity: Moderate
Bumetanide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide promotes sodium loss, and trazodone has been associated with SIADH-related hyponatremia, mainly in older patients. Combining them may increase the chance of low sodium. Trazodone can also add to orthostatic hypotension from diuresis.
What this interaction means in plain words
Bumetanide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on sodium balance: diuretic natriuresis plus antidepressant-associated SIADH.
What to do
Monitor serum sodium after starting or changing doses, particularly in elderly patients. Also watch for orthostatic hypotension and adjust therapy if hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Bumetanide with Trazodone?
MediHelp rates the interaction as moderate. Bumetanide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide promotes sodium loss, and trazodone has been associated with SIADH-related hyponatremia, mainly in older patients. Combining them may increase the chance of low sodium. Trazodone can also add to orthostatic hypotension from diuresis.
How serious is the interaction between Bumetanide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium after starting or changing doses, particularly in elderly patients. Also watch for orthostatic hypotension and adjust therapy if hyponatremia develops.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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