Drug interactions
Bupropion + Prochlorperazine
Severity: Moderate
Bupropion and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can lower the seizure threshold, adding to bupropion's seizure risk. Bupropion's CYP2D6 inhibition may also modestly raise phenothiazine levels.
What this interaction means in plain words
Bupropion and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold, with possible CYP2D6 inhibition by bupropion.
What to do
Use the lowest effective doses, avoid in patients with seizure history, and monitor for seizures and extrapyramidal effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Bupropion with Prochlorperazine?
MediHelp rates the interaction as moderate. Bupropion and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine can lower the seizure threshold, adding to bupropion's seizure risk. Bupropion's CYP2D6 inhibition may also modestly raise phenothiazine levels.
How serious is the interaction between Bupropion and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, avoid in patients with seizure history, and monitor for seizures and extrapyramidal effects.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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