Drug interactions
Bupropion-naltrexone + Chlorpromazine
Severity: Major
Bupropion-naltrexone and Chlorpromazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both bupropion and chlorpromazine lower the seizure threshold, so combined use raises the risk of seizures. Bupropion also inhibits CYP2D6 and may increase chlorpromazine levels.
What this interaction means in plain words
Bupropion-naltrexone and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive lowering of the seizure threshold, plus CYP2D6 inhibition by bupropion that raises chlorpromazine exposure.
What to do
Avoid if possible. If combined, use the lowest effective doses, titrate slowly and monitor for seizures and antipsychotic adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Chlorpromazine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both bupropion and chlorpromazine lower the seizure threshold, so combined use raises the risk of seizures. Bupropion also inhibits CYP2D6 and may increase chlorpromazine levels.
How serious is the interaction between Bupropion-naltrexone and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If combined, use the lowest effective doses, titrate slowly and monitor for seizures and antipsychotic adverse effects.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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