Drug interactions
Bupropion-naltrexone + Lisdexamfetamine
Severity: Moderate
Bupropion-naltrexone and Lisdexamfetamine: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both bupropion and amphetamines can lower the seizure threshold, so seizure risk is additive. Combined stimulant effects may also raise blood pressure and heart rate.
What this interaction means in plain words
Bupropion-naltrexone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic lowering of seizure threshold and noradrenergic/dopaminergic stimulation.
What to do
Avoid in patients with seizure history, and monitor blood pressure, heart rate and neurological symptoms. Keep doses at the lowest effective levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both bupropion and amphetamines can lower the seizure threshold, so seizure risk is additive. Combined stimulant effects may also raise blood pressure and heart rate.
How serious is the interaction between Bupropion-naltrexone and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure history, and monitor blood pressure, heart rate and neurological symptoms. Keep doses at the lowest effective levels.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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