Drug interactions
Caffeine + Givosiran
Severity: Moderate
Caffeine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran may inhibit CYP1A2 and raise exposure to sensitive substrates. Caffeine is a CYP1A2 substrate, so levels may rise and cause jitteriness, tachycardia and insomnia.
What this interaction means in plain words
Caffeine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Givosiran belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism by givosiran.
What to do
Advise patients to limit caffeine intake and monitor for stimulant effects such as palpitations and insomnia during givosiran therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Caffeine with Givosiran?
MediHelp rates the interaction as moderate. Caffeine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran may inhibit CYP1A2 and raise exposure to sensitive substrates. Caffeine is a CYP1A2 substrate, so levels may rise and cause jitteriness, tachycardia and insomnia.
How serious is the interaction between Caffeine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to limit caffeine intake and monitor for stimulant effects such as palpitations and insomnia during givosiran therapy.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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