Drug interactions
Caffeine + Solriamfetol
Severity: Moderate
Caffeine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol can raise blood pressure and heart rate, and caffeine may add to these effects along with insomnia and anxiety. This matters most in patients with hypertension or cardiovascular disease.
What this interaction means in plain words
Caffeine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive sympathomimetic and CNS stimulation: solriamfetol inhibits dopamine and norepinephrine reuptake while caffeine blocks adenosine receptors.
What to do
Monitor blood pressure and heart rate, especially after starting or adjusting solriamfetol, and advise limiting caffeine intake.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Caffeine with Solriamfetol?
MediHelp rates the interaction as moderate. Caffeine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol can raise blood pressure and heart rate, and caffeine may add to these effects along with insomnia and anxiety. This matters most in patients with hypertension or cardiovascular disease.
How serious is the interaction between Caffeine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially after starting or adjusting solriamfetol, and advise limiting caffeine intake.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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