Drug interactions
Calcifediol + Clarithromycin
Severity: Moderate
Calcifediol and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP inhibitors may alter calcifediol metabolism and reduce conversion to active calcitriol. This could change serum 25-hydroxyvitamin D levels and calcium handling.
What this interaction means in plain words
Calcifediol and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP enzymes involved in vitamin D hydroxylation and catabolism alters calcifediol disposition.
What to do
Monitor serum 25-hydroxyvitamin D, PTH and calcium when starting or stopping clarithromycin and adjust the calcifediol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Clarithromycin?
MediHelp rates the interaction as moderate. Calcifediol and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP inhibitors may alter calcifediol metabolism and reduce conversion to active calcitriol. This could change serum 25-hydroxyvitamin D levels and calcium handling.
How serious is the interaction between Calcifediol and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, PTH and calcium when starting or stopping clarithromycin and adjust the calcifediol dose accordingly.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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