Drug interactions
Calcifediol + Itraconazole
Severity: Moderate
Calcifediol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcifediol is cleared partly by CYP3A4-mediated hydroxylation, so itraconazole may increase exposure to calcifediol and its active metabolite. This may raise the likelihood of hypercalcemia.
What this interaction means in plain words
Calcifediol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition slows catabolism of calcifediol.
What to do
Monitor serum calcium, phosphate and PTH when itraconazole is started or stopped. Adjust the calcifediol dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Itraconazole?
MediHelp rates the interaction as moderate. Calcifediol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcifediol is cleared partly by CYP3A4-mediated hydroxylation, so itraconazole may increase exposure to calcifediol and its active metabolite. This may raise the likelihood of hypercalcemia.
How serious is the interaction between Calcifediol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH when itraconazole is started or stopped. Adjust the calcifediol dose as needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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