Drug interactions
Calcifediol + Ribociclib
Severity: Minor
Calcifediol and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcifediol is converted by CYP27B1 and cleared partly by CYP24A1, with CYP3A4 playing a minor role. Any rise in exposure caused by ribociclib is unlikely to matter clinically.
What this interaction means in plain words
Calcifediol and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by ribociclib; the clinical relevance is unestablished.
What to do
No action is needed beyond routine monitoring of serum calcium and parathyroid hormone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Ribociclib?
MediHelp rates the interaction as minor. Calcifediol and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcifediol is converted by CYP27B1 and cleared partly by CYP24A1, with CYP3A4 playing a minor role. Any rise in exposure caused by ribociclib is unlikely to matter clinically.
How serious is the interaction between Calcifediol and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring of serum calcium and parathyroid hormone.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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