Drug interactions
Calcifediol + Voriconazole
Severity: Moderate
Calcifediol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP inhibitors may alter the metabolism of calcifediol and its activation to calcitriol. This could change vitamin D status and calcium handling, although the clinical impact is not well characterized.
What this interaction means in plain words
Calcifediol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP-mediated vitamin D metabolism may alter calcifediol clearance and conversion to calcitriol; the clinical relevance is not well established.
What to do
Monitor serum calcium, PTH and 25-hydroxyvitamin D when voriconazole is started or stopped, and adjust the calcifediol dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Voriconazole?
MediHelp rates the interaction as moderate. Calcifediol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP inhibitors may alter the metabolism of calcifediol and its activation to calcitriol. This could change vitamin D status and calcium handling, although the clinical impact is not well characterized.
How serious is the interaction between Calcifediol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, PTH and 25-hydroxyvitamin D when voriconazole is started or stopped, and adjust the calcifediol dose as needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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