Drug interactions
Calcitriol + Pacritinib
Severity: Minor
Calcitriol and Pacritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcitriol is a weak CYP3A4 inducer in some contexts, and a meaningful reduction in pacritinib exposure is unlikely at usual doses. The pairing is largely theoretical.
What this interaction means in plain words
Calcitriol and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Pacritinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 induction by calcitriol; not clearly established clinically.
What to do
No routine adjustment is needed; monitor response to pacritinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Calcitriol with Pacritinib?
MediHelp rates the interaction as minor. Calcitriol and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcitriol is a weak CYP3A4 inducer in some contexts, and a meaningful reduction in pacritinib exposure is unlikely at usual doses. The pairing is largely theoretical.
How serious is the interaction between Calcitriol and Pacritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor response to pacritinib.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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