Drug interactions
Calcitriol + Posaconazole
Severity: Moderate
Calcitriol and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole strongly inhibits CYP3A4 and may increase calcitriol levels. Higher exposure can lead to hypercalcemia, particularly during long antifungal courses or prophylaxis.
What this interaction means in plain words
Calcitriol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated catabolism of calcitriol by posaconazole.
What to do
Monitor serum calcium regularly during posaconazole therapy and reduce the calcitriol dose if calcium rises. Recheck calcium after posaconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Calcitriol with Posaconazole?
MediHelp rates the interaction as moderate. Calcitriol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole strongly inhibits CYP3A4 and may increase calcitriol levels. Higher exposure can lead to hypercalcemia, particularly during long antifungal courses or prophylaxis.
How serious is the interaction between Calcitriol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly during posaconazole therapy and reduce the calcitriol dose if calcium rises. Recheck calcium after posaconazole is stopped.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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