Drug interactions
Calcium + Vismodegib
Severity: Minor
Calcium and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib solubility is pH dependent, so calcium carbonate that raises gastric pH may lower its absorption. The clinical effect on efficacy is not known.
What this interaction means in plain words
Calcium and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Elevated gastric pH reduces vismodegib solubility and bioavailability.
What to do
Labeling indicates no dose change is needed. Consider separating antacid and vismodegib by a couple of hours and monitor tumor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Calcium with Vismodegib?
MediHelp rates the interaction as minor. Calcium and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vismodegib solubility is pH dependent, so calcium carbonate that raises gastric pH may lower its absorption. The clinical effect on efficacy is not known.
How serious is the interaction between Calcium and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling indicates no dose change is needed. Consider separating antacid and vismodegib by a couple of hours and monitor tumor response.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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