Drug interactions
Calcium carbonate + Lisdexamfetamine
Severity: Minor
Calcium carbonate and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Urinary alkalinization reduces amphetamine excretion and may prolong its effects. Calcium carbonate alkalinizes urine only mildly, so the impact is usually minor.
What this interaction means in plain words
Calcium carbonate and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Alkaline urine increases tubular reabsorption of amphetamine, reducing its renal clearance.
What to do
Monitor for increased stimulant effects such as tachycardia or insomnia if large antacid doses are used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Lisdexamfetamine?
MediHelp rates the interaction as minor. Calcium carbonate and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Urinary alkalinization reduces amphetamine excretion and may prolong its effects. Calcium carbonate alkalinizes urine only mildly, so the impact is usually minor.
How serious is the interaction between Calcium carbonate and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects such as tachycardia or insomnia if large antacid doses are used regularly.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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