Drug interactions
Calcium carbonate + Posaconazole
Severity: Minor
Calcium carbonate and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension absorption depends on gastric acidity, and acid-reducing agents may lower exposure. Antacids showed little effect in labeling studies, so clinical significance is limited.
What this interaction means in plain words
Calcium carbonate and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Raised gastric pH could reduce posaconazole dissolution, though antacid effects are minimal.
What to do
No dose adjustment is usually required. Consider posaconazole level monitoring if antifungal response is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Posaconazole?
MediHelp rates the interaction as minor. Calcium carbonate and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole oral suspension absorption depends on gastric acidity, and acid-reducing agents may lower exposure. Antacids showed little effect in labeling studies, so clinical significance is limited.
How serious is the interaction between Calcium carbonate and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Consider posaconazole level monitoring if antifungal response is a concern.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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