Drug interactions
Canagliflozin + Digoxin
Severity: Moderate
Canagliflozin and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin modestly raises digoxin exposure in pharmacokinetic studies. Because digoxin has a narrow therapeutic index, this may contribute to digoxin toxicity in susceptible patients.
What this interaction means in plain words
Canagliflozin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Digoxin belongs to Cardiovascular.
Why it happens
Canagliflozin likely inhibits P-glycoprotein, reducing digoxin efflux and clearance.
What to do
Monitor serum digoxin concentrations and clinical signs of toxicity when canagliflozin is started or stopped. Adjust the digoxin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Digoxin?
MediHelp rates the interaction as moderate. Canagliflozin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin modestly raises digoxin exposure in pharmacokinetic studies. Because digoxin has a narrow therapeutic index, this may contribute to digoxin toxicity in susceptible patients.
How serious is the interaction between Canagliflozin and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical signs of toxicity when canagliflozin is started or stopped. Adjust the digoxin dose as needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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