Drug interactions
Canagliflozin + Glipizide
Severity: Moderate
Canagliflozin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin lowers glucose through urinary excretion, and combined with glipizide it increases the risk of hypoglycemia. Labeling advises a lower dose of the insulin secretagogue.
What this interaction means in plain words
Canagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering: SGLT2 inhibition promotes glucosuria while glipizide stimulates insulin secretion.
What to do
Consider lowering the glipizide dose when adding canagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glipizide
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Glipizide?
MediHelp rates the interaction as moderate. Canagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin lowers glucose through urinary excretion, and combined with glipizide it increases the risk of hypoglycemia. Labeling advises a lower dose of the insulin secretagogue.
How serious is the interaction between Canagliflozin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when adding canagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
