Drug interactions
Canagliflozin + Insulin degludec-insulin aspart
Severity: Moderate
Canagliflozin and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding canagliflozin to insulin lowers glucose further and increases the risk of hypoglycemia. SGLT2 inhibitors together with insulin also carry a risk of euglycemic diabetic ketoacidosis, especially if insulin doses are cut too far.
What this interaction means in plain words
Canagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive glucose lowering through different mechanisms: insulin action plus SGLT2-mediated urinary glucose excretion.
What to do
Consider reducing the insulin dose when starting canagliflozin and monitor blood glucose closely. Check for ketosis if the patient is unwell, and avoid abrupt large insulin reductions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Canagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding canagliflozin to insulin lowers glucose further and increases the risk of hypoglycemia. SGLT2 inhibitors together with insulin also carry a risk of euglycemic diabetic ketoacidosis, especially if insulin doses are cut too far.
How serious is the interaction between Canagliflozin and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting canagliflozin and monitor blood glucose closely. Check for ketosis if the patient is unwell, and avoid abrupt large insulin reductions.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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