Drug interactions
Captopril-hydrochlorothiazide + Dexmethylphenidate
Severity: Moderate
Captopril-hydrochlorothiazide and Dexmethylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate is a stimulant that can raise blood pressure and heart rate. It may reduce the effectiveness of captopril and hydrochlorothiazide, leading to poorer blood pressure control.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dexmethylphenidate belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor effects of dexmethylphenidate oppose the antihypertensive action of the ACE inhibitor and diuretic.
What to do
Monitor blood pressure when starting or increasing the stimulant. Intensify antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dexmethylphenidate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmethylphenidate is a stimulant that can raise blood pressure and heart rate. It may reduce the effectiveness of captopril and hydrochlorothiazide, leading to poorer blood pressure control.
How serious is the interaction between Captopril-hydrochlorothiazide and Dexmethylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or increasing the stimulant. Intensify antihypertensive therapy if control is lost.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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