Drug interactions
Captopril-hydrochlorothiazide + Givosiran
Severity: Minor
Captopril-hydrochlorothiazide and Givosiran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6 and raise exposure to sensitive substrates of that enzyme. Captopril is not a sensitive CYP2D6 substrate and has a wide margin of safety, so clinically significant changes are unlikely.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Givosiran belongs to Miscellaneous.
Why it happens
Weak to moderate CYP2D6 inhibition by givosiran may slightly slow captopril metabolism.
What to do
No dose change is generally required; monitor blood pressure after starting givosiran.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Givosiran?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can moderately inhibit CYP2D6 and raise exposure to sensitive substrates of that enzyme. Captopril is not a sensitive CYP2D6 substrate and has a wide margin of safety, so clinically significant changes are unlikely.
How serious is the interaction between Captopril-hydrochlorothiazide and Givosiran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor blood pressure after starting givosiran.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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