Drug interactions
Captopril-hydrochlorothiazide + Rolapitant
Severity: Minor
Captopril-hydrochlorothiazide and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a long-acting CYP2D6 inhibitor and may raise concentrations of CYP2D6 substrates. Captopril is only partly metabolized by CYP2D6 and its clinical impact is likely small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2D6 by rolapitant, which has a minor role in captopril disposition.
What to do
No dose change is usually needed; monitor blood pressure if the patient receives repeated rolapitant courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Rolapitant?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rolapitant is a long-acting CYP2D6 inhibitor and may raise concentrations of CYP2D6 substrates. Captopril is only partly metabolized by CYP2D6 and its clinical impact is likely small.
How serious is the interaction between Captopril-hydrochlorothiazide and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure if the patient receives repeated rolapitant courses.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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