Drug interactions
Carbamazepine + Elagolix
Severity: Moderate
Carbamazepine and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce elagolix exposure and efficacy, while elagolix, a weak-to-moderate CYP3A inducer, may lower carbamazepine levels. Both effects can reduce therapeutic benefit, including seizure control.
What this interaction means in plain words
Carbamazepine and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Elagolix belongs to Musculoskeletal.
Why it happens
Mutual induction of CYP3A4 metabolism, with carbamazepine also lowering elagolix exposure.
What to do
Monitor carbamazepine concentrations and seizure control and monitor endometriosis symptoms. Consider an alternative anticonvulsant or therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Carbamazepine with Elagolix?
MediHelp rates the interaction as moderate. Carbamazepine and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce elagolix exposure and efficacy, while elagolix, a weak-to-moderate CYP3A inducer, may lower carbamazepine levels. Both effects can reduce therapeutic benefit, including seizure control.
How serious is the interaction between Carbamazepine and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine concentrations and seizure control and monitor endometriosis symptoms. Consider an alternative anticonvulsant or therapy if efficacy is lost.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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