Drug interactions
Carbamazepine + Enfortumab vedotin
Severity: Minor
Carbamazepine and Enfortumab vedotin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enfortumab vedotin releases MMAE, a CYP3A4 substrate, and carbamazepine may lower its exposure. Reduced exposure could weaken efficacy, although the effect is predicted rather than well studied.
What this interaction means in plain words
Carbamazepine and Enfortumab vedotin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Enfortumab vedotin belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, which may increase clearance of the released MMAE.
What to do
No dose change is required. Monitor treatment response and consider a non-inducing anticonvulsant if loss of efficacy is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Carbamazepine with Enfortumab vedotin?
MediHelp rates the interaction as minor. Carbamazepine and Enfortumab vedotin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enfortumab vedotin releases MMAE, a CYP3A4 substrate, and carbamazepine may lower its exposure. Reduced exposure could weaken efficacy, although the effect is predicted rather than well studied.
How serious is the interaction between Carbamazepine and Enfortumab vedotin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor treatment response and consider a non-inducing anticonvulsant if loss of efficacy is suspected.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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